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Article

Antioxidant treatment induces transcription and expression of transforming growth factor beta in cultured renal proximal tubular cells.

FEBS letters - 19 Jan 2001

Wolf G, Hannken T, Schroeder R, Zahner G, Ziyadeh F N, Stahl R A

Abstract excerpt

Transforming growth factor beta (TGF-beta) plays an important role in the development of tubulointerstitial fibrosis in chronic renal disease. We were interested whether interference with oxygen radicals may modulate TGF-beta expression. Unexpectedly, we discovered that diphenylene iodine (DIP), an inhibitor of NADP(H) oxidase, induces a robust increase in TGF-beta transcript expression in cultured mouse proximal...

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Identifiers

PMID: 11163763
DOI: 10.1016/s0014-5793(00)02403-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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