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Article

Oncolytic Viruses: The Power of Directed Evolution

24 Jul 2011

Abstract excerpt

Attempts at developing oncolytic viruses have been primarily based on rational design. However, this approach has been met with limited success. An alternative approach employs directed evolution as a means of producing highly selective and potent anticancer viruses. In this method, diverse viruses are grown under conditions that maximize diversity and then passaged under conditions meant to mimic those...

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PMID: 22312363
DOI: 10.1155/2012/586389

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