Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Singularity: the Achilles' heel of cancer?

Medical hypotheses - 1 Oct 2009

Boyde T R C

Abstract excerpt

It is predicted that the total number of mutations present at the first appearance of a fully malignant clone, including passengers, is so large that every individual patient's cancer is unique from the outset. The initiating (malignant-clone-defining) mutation set (McDMS) defines the cancer, per...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Genetic Variation
Share to Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Source

Identifiers

PMID: 19632791
DOI: 10.1016/j.mehy.2009.06.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19632791-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Singularity: the Achilles' heel of cancer?PMID 19632791Read ↗

Nothing in cancer makes sense except….Semantic proximity Read ↗

Cancer: the emerging molecular biology.Semantic proximity Read ↗

Tracing the path of cancer initiation: the AA protein-based model for cancer genesis.Semantic proximity Read ↗

Embracing cancer complexity: Hallmarks of systemic diseaseSemantic proximity Read ↗

Multidimensional complexity of cancer. Simple solutions are neededSemantic proximity Read ↗

Thinking Cancer.Semantic proximity Read ↗

The multistep nature of cancer.Semantic proximity Read ↗

[A reductionnist approach of cancer].Semantic proximity Read ↗

Cancer Clonal Theory, Immune Escape, and Their Evolving Roles in Cancer Multi-Agent Therapeutics.Semantic proximity Read ↗

The Cheating Cell: How Evolution Helps Us Understand and Treat CancerSemantic proximity Read ↗

Targeting cancer's weaknesses (not its strengths): Therapeutic strategies suggested by the atavistic model.Semantic proximity Read ↗

A Law of Redundancy Compounds the Problem of Cancer and Precision Medicine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.