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Article

Adipoclast: a multinucleated fat-eating macrophage

18 Nov 2021

Abstract excerpt

Cell membrane fusion and multinucleation in macrophages are associated with physiologic homeostasis as well as disease. Osteoclasts are multinucleated macrophages that resorb bone through increased metabolic activity resulting from cell fusion. Fusion of macrophages also generates multinucleated giant cells (MGCs) in white adipose tissue (WAT) of obese individuals. For years, our knowledge of MGCs in WAT has been...

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PMID: 34794433
DOI: 10.1186/s12915-021-01181-3

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