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The Formation and Function of Granulomas

5 Feb 2018

Abstract excerpt

Granulomas are organized aggregates of macrophages, often with characteristic morphological changes, and other immune cells. These evolutionarily ancient structures form in response to persistent particulate stimuli-infectious or noninfectious-that individual macrophages cannot eradicate. Granulomas evolved as protective responses to destroy or sequester particles but are frequently pathological in the context of...

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PMID: 29400999
DOI: 10.1146/annurev-immunol-032712-100022

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