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Design of High-Throughput Screening of Natural Extracts to Identify Molecules Bypassing Primary Coenzyme Q Deficiency in Saccharomyces cerevisiae.

SLAS discovery : advancing life sciences R & D - 1 Mar 2020

Berenguel Hernández Aida M, de la Cruz Mercedes, Alcázar-Fabra María, Prieto-Rodríguez Andrés, Sánchez-Cuesta Ana, Martin Jesús, Tormo José R, Rodríguez-Aguilera Juan Carlos, Cortés-Rodríguez Ana Belén, Navas Plácido, Reyes Fernando, Vicente Francisca, Genilloud Olga, Santos-Ocaña Carlos

Abstract excerpt

Coenzyme Q10 (CoQ10) deficiency syndrome is a rare disease included in the family of mitochondrial diseases, which is a heterogeneous group of genetic disorders characterized by defective energy production. CoQ10 biosynthesis in humans requires at least 11 gene products acting in a multiprotein complex within mitochondria. The high-throughput screening (HTS) method based on the stabilization of the CoQ...

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PMID: 31751168
DOI: 10.1177/2472555219877185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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