Article
Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants.
Biochimica et biophysica acta - 1 May 2011
Xie Letian X, Hsieh Edward J, Watanabe Shota, Allan Christopher M, Chen Jia Y, Tran UyenPhuong C, Clarke Catherine F
Abstract excerpt
Coenzyme Q (ubiquinone or Q) is a lipid electron and proton carrier in the electron transport chain. In yeast Saccharomyces cerevisiae eleven genes, designated COQ1 through COQ9, YAH1 and ARH1, have been identified as being required for Q biosynthesis. One of these genes, COQ8 (ABC1), encodes an atypical protein kinase, containing six (I, II, III, VIB, VII, and VIII) of the twelve motifs characteristically...
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