Article
Consensus molecular subtype classification of colorectal adenomas.
The Journal of pathology - 1 Nov 2018
Komor Malgorzata A, Bosch Linda Jw, Bounova Gergana, Bolijn Anne S, Delis-van Diemen Pien M, Rausch Christian, Hoogstrate Youri, Stubbs Andrew P, de Jong Mark, Jenster Guido, van Grieken Nicole Ct, Carvalho Beatriz, Wessels Lodewyk Fa, Jimenez Connie R, Fijneman Remond Ja, Meijer Gerrit A
Abstract excerpt
Consensus molecular subtyping is an RNA expression-based classification system for colorectal cancer (CRC). Genomic alterations accumulate during CRC pathogenesis, including the premalignant adenoma stage, leading to changes in RNA expression. Only a minority of adenomas progress to malignancies, a transition that is associated with specific DNA copy number aberrations or microsatellite instability (MSI). We...
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