Article

MIRO2 regulates prostate cancer cell growth via GCN1-dependent stress signaling

2021-05-21

Abstract excerpt

<h4>ABSTRACT</h4> There is a continued need to identify novel therapeutic targets to prevent the mortality associated with prostate cancer. In this context, we discovered a novel mitochondrial signaling pathway that controls androgen-independent and androgen-sensitive prostate cancer cell growth. Mitochondrial Rho GTPase 2 ( MIRO2 ) mRNA was upregulated in prostate cancer compared to localized tumors, and higher...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ddc54721-ee5e-53bb-b0eb-27b062baa53f
DOI: 10.1101/2021.05.20.444992

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MIRO2 regulates prostate cancer cell growth via GCN1-dependent stress signalingDOI 10.1101/2021.05.20.444992Read

MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress SignalingSemantic proximity Read

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasisSemantic proximity Read

NETO2 promotes progression of prostate cancer by inhibiting the cellular senescence pathwaySemantic proximity Read

Mitochondrial SLC25A10 promotes prostate cancer progression by inhibiting ferritinophagySemantic proximity Read

MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancerSemantic proximity Read

MZF1-mediated GAPDH overexpression drives glycolytic reprogramming and neuroendocrine progression in advanced prostate cancerSemantic proximity Read

Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphateSemantic proximity Read

Mechanistic Link Between Glyoxalase 1 Expression and Methylglyoxal-Induced Oncogenic Stress in Prostate CancerSemantic proximity Read

Secreted spermidine synthase reveals a paracrine role for PGC1α-induced growth suppression in prostate cancerSemantic proximity Read

Glutamine transporters regulate prostate cancer radiosensitivity through NUPR1-mediated stress responseSemantic proximity Read

Mitochondrial Alterations in Prostate Cancer: Roles in Pathobiology and Racial DisparitiesSemantic proximity Read

Androgen deprivation induces double-null prostate cancer via aberrant nuclear export and ribosomal biogenesis through HGF and Wnt activationSemantic proximity Read