Article

Huntingtin Over-Expression Does Not Alter Overall Survival in Murine Cancer Models

2022-09-13

Abstract excerpt

<h4>ABSTRACT</h4> A reduced incidence of various forms of cancer has been reported in Huntington’s disease (HD) patients and may be due to pro-apoptotic effects of mutant huntingtin. We tested this hypothesis by assessing the effects of huntingtin protein over-expression on survival in two murine cancer models. We generated yeast artificial chromosome (YAC) HD mice containing human huntingtin transgenes with vari...

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Literature Corpus work: 361071b7-421a-58ea-99a9-9a2b4a94d792
DOI: 10.1101/2022.09.11.507440

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