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Article

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo.

American journal of human genetics - 1 Feb 2001

Leavitt B R, Guttman J A, Hodgson J G, Kimel G H, Singaraja R, Vogl A W, Hayden M R

Abstract excerpt

We have developed yeast artificial chromosome (YAC) transgenic mice expressing normal (YAC18) and mutant (YAC46 or YAC72) human huntingtin (htt), in a developmental- and tissue-specific manner, that is identical to endogenous htt. YAC72 mice develop selective degeneration of medium spiny projection neurons in the lateral striatum, similar to what is observed in Huntington disease. Mutant human htt expressed by...

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Identifiers

PMID: 11133364
DOI: 10.1086/318207
PMCID: PMC1235265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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