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Article

Lifetime risk of cancer in carriers of intermediate alleles in the HTT gene.

Scientific reports - 16 Jan 2026

Sundblom Jimmy, Bergdahl Ingvar, Stattin Eva-Lena, Niemelä Valter

Abstract excerpt

Previous studies have found a markedly reduced risk of cancer among Huntington’s disease (HD) patients with CAG ≥ 40, but data on cancer risk at shorter repeat numbers are lacking. The study includes 8149 subjects from Northern Sweden Health and Disease Study. Genotyping yielded a large number of intermediate allele carriers (IA, CAGn 27–35, (n = 497), normal alleles (CAGn 17–26,n = 6584), short alleles...

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Identifiers

PMID: 41545439
DOI: 10.1038/s41598-026-35941-4
PMCID: PMC12820381

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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