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Article

Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript.

Human molecular genetics - 1 Feb 1996

Goldberg Y P, Kalchman M A, Metzler M, Nasir J, Zeisler J, Graham R, Koide H B, O'Kusky J, Sharp A H, Ross C A, Jirik F, Hayden M R

Abstract excerpt

The mutation underlying Huntington disease (HD) is CAG expansion in the first exon of the HD gene. In order to investigate the role of CAG expansion in the pathogenesis of HD, we have produced transgenic mice containing the full length human HD cDNA with 44 CAG repeats. By 1 year, these mice have no behavioral abnormalities and morphometric analysis at 6 (one animal) and 9 (two animals) months age revealed no...

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PMID: 8824873
DOI: 10.1093/hmg/5.2.177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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