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Article

CAG repeat size in Huntingtin alleles is associated with cancer prognosis.

European journal of human genetics : EJHG - 1 Aug 2016

Thion Morgane Sonia, Tézenas du Montcel Sophie, Golmard Jean-Louis, Vacher Sophie, Barjhoux Laure, Sornin Valérie, Cazeneuve Cécile, Bièche Ivan, Sinilnikova Olga, Stoppa-Lyonnet Dominique, Durr Alexandra, Humbert Sandrine

Abstract excerpt

The abnormal expansion of a ≥36 CAG unit tract in the Huntingtin gene (HTT) leads to Huntington's disease (HD), but has also been associated with cancer: the incidence of cancer is lower in HD patients than in age-matched controls, but HD-causing variants of HTT accelerate the progression of breast tumors and the development of metastases in mouse models of breast cancer. To investigate the relationship between...

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Source

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Identifiers

PMID: 26980106
DOI: 10.1038/ejhg.2016.13
PMCID: PMC4989202

Genes

HTT
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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