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Article

An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2012

Chakkalakal Salin A, Zhang Deyu, Culbert Andria L, Convente Michael R, Caron Robert J, Wright Alexander C, Maidment Andrew D A, Kaplan Frederick S, Shore Eileen M

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP; MIM #135100) is a debilitating genetic disorder of dysregulated cellular differentiation characterized by malformation of the great toes during embryonic skeletal development and by progressive heterotopic endochondral ossification postnatally. Patients with these classic clinical features of FOP have the identical heterozygous single nucleotide substitution...

Topics

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Activin Receptors, Type I
Chondrogenesis
Connective Tissue
Gene Knock-In Techniques
Myositis Ossificans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ossification, Heterotopic

Receptor, TIE-2

Source

Open in PubMed Open full text

Identifiers

PMID: 22508565
DOI: 10.1002/jbmr.1637
PMCID: PMC3556640

Genes

ACVR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva.PMID 22508565Read ↗

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