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Article

Fibrodysplasia ossificans progressiva mutant ACVR1 signals by multiple modalities in the developing zebrafish

8 Sept 2020

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP) is a rare human genetic disorder characterized by altered skeletal development and extraskeletal ossification. All cases of FOP are caused by activating mutations in the type I BMP/TGFβ cell surface receptor ACVR1, which over-activates signaling through phospho-Smad1/5 (pSmad1/5). To investigate the mechanism by which FOP-ACVR1 enhances pSmad1/5 activation, we used...

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PMID: 32897189
DOI: 10.7554/elife.53761

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Fibrodysplasia ossificans progressiva mutant ACVR1 signals by multiple modalities in the developing zebrafishPMID 32897189Read ↗

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