Article
A New Chromatin-Cytoskeleton Link in Cancer.
Molecular cancer research : MCR - 1 Dec 2016
Giaccia Amato J
Abstract excerpt
The set domain containing 2 (SETD2) histone methyltransferase, located at 3p2, specifically trimethylates lysine 36 of histone H3 (H3K36me3). H3K36me3 is an active mark involved in transcriptional elongation and RNA processing and a key regulator of DNA repair. In fact, SETD2 is the only methyltr...
Topics
- Chromatin
- Cytoskeleton
- Genomic Instability
- Histone-Lysine N-Methyltransferase
- Histones
- Humans
- Lysine
- Methylation
- Mutation
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Neoplasms
- Tubulin