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Article

A New Chromatin-Cytoskeleton Link in Cancer.

Molecular cancer research : MCR - 1 Dec 2016

Giaccia Amato J

Abstract excerpt

The set domain containing 2 (SETD2) histone methyltransferase, located at 3p2, specifically trimethylates lysine 36 of histone H3 (H3K36me3). H3K36me3 is an active mark involved in transcriptional elongation and RNA processing and a key regulator of DNA repair. In fact, SETD2 is the only methyltransferase that "writes" the H3K36me3 mark. Recent results from Park and colleagues have found a new role for SETD2 in...

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Source

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Identifiers

PMID: 27528705
DOI: 10.1158/1541-7786.MCR-16-0250
PMCID: PMC5136307

Genes

SETD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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