Article

Significance testing for small annotations in stratified LD-Score regression

2021-03-24

Abstract excerpt

S-LDSC is a widely used heritability enrichment method that has helped gain biological insights into numerous complex traits. It has primarily been used to analyze large annotations that contain approximately 0.5% of SNPs or more. Here, we show in simulation that, when applied to small annotations, the block jackknife-based significance testing used in S-LDSC does not always control type 1 error. We show that the...

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Literature Corpus work: 35e0167c-97c3-5b3d-bbb5-015020f7668f
DOI: 10.1101/2021.03.13.21249938

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