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Article

Improved estimation of functional enrichment in SNP heritability using feasible generalized least squares.

HGG advances - 11 Apr 2024

Xiong Zewei, Thach Thuan-Quoc, Zhang Yan Dora, Sham Pak Chung

Abstract excerpt

Functional enrichment results typically implicate tissue or cell-type-specific biological pathways in disease pathogenesis and as therapeutic targets. We propose generalized linkage disequilibrium score regression (g-LDSC) that requires only genome-wide association studies (GWASs) summary-level data to estimate functional enrichment. The method adopts the same assumptions and regression model formulation as...

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Identifiers

PMID: 38327050
DOI: 10.1016/j.xhgg.2024.100272
PMCID: PMC10901842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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