Article
Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli.
PLoS pathogens - 1 Jul 2023
Malaga Wladimir, Payros Delphine, Meunier Eva, Frigui Wafa, Sayes Fadel, Pawlik Alexandre, Orgeur Mickael, Berrone Céline, Moreau Flavie, Mazères Serge, Gonzalo-Asensio Jesus, Rengel David, Martin Carlos, Astarie-Dequeker Catherine, Mourey Lionel, Brosch Roland, Guilhot Christophe
Abstract excerpt
The molecular factors and genetic adaptations that contributed to the emergence of Mycobacterium tuberculosis (MTB) from an environmental Mycobacterium canettii-like ancestor, remain poorly investigated. In MTB, the PhoPR two-component regulatory system controls production and secretion of proteins and lipid virulence effectors. Here, we describe that several mutations, present in phoR of M. canettii relative to...
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