Article
Senescent cells and the dynamics of aging
2018-11-14
Abstract excerpt
A causal factor in mammalian aging is the accumulation of senescent cells (SnCs) with age. SnCs cause chronic inflammation, and removing SnCs decelerates aging in mice. Despite their importance, however, the production and removal rates of SnCs are not known, and their connection to aging dynamics is unclear. Here we use longitudinal SnC measurements and SnC induction experiments to show that SnCs turn over rapidl...
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Identifiers and source
- Literature Corpus work
- 35aedd75-1e72-54d3-87cd-b65e6da6d0c8
- DOI
- 10.1101/470500