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Article

Different Mechanisms of Longevity in Long-Lived Mouse and Caenorhabditis elegans Mutants Revealed by Statistical Analysis of Mortality Rates.

Genetics - 1 Nov 2016

Hughes Bryan G, Hekimi Siegfried

Abstract excerpt

Mouse and Caenorhabditis elegans mutants with altered life spans are being used to investigate the aging process and how genes determine life span. The survival of a population can be modeled by the Gompertz function, which comprises two parameters. One of these parameters ("G") describes the rate at which mortality accelerates with age and is often described as the "rate of aging." The other parameter ("A") may...

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Identifiers

PMID: 27638422
DOI: 10.1534/genetics.116.192369
PMCID: PMC5105868

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