Article

Machine learning predicts lifespan and underlying causes of death in aging C. elegans

2024-05-07

Abstract excerpt

<title>Abstract</title> <p>Senescence (aging) leads to senescent pathology that causes death, and genes control aging by determining such pathology. Here we investigate how senescent pathology mediates the effect of genotype on lifespan in C. elegans by means of a data-driven approach, using machine learning (ML). To achieve this we gathered extensive data on how diverse determinants of lifespan (sex, nutrition,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd1d95dd-cc1b-5fbb-88a2-cad93a790b93
DOI: 10.21203/rs.3.rs-4131896/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Machine learning predicts lifespan and underlying causes of death in aging C. elegansDOI 10.21203/rs.3.rs-4131896/v1Read

Machine learning predicts lifespan and underlying causes of death in aging <i>C. elegans</i>Semantic proximity Read

Two forms of death in ageing Caenorhabditis elegans.Semantic proximity Read

Different Mechanisms of Longevity in Long-Lived Mouse and Caenorhabditis elegans Mutants Revealed by Statistical Analysis of Mortality Rates.Semantic proximity Read

Multidimensional phenotyping predicts lifespan and quantifies health in Caenorhabditis elegans.Semantic proximity Read

Deep behavioural phenotyping reveals divergent trajectories of ageing and quantifies health state in <i>C. elegans</i>Semantic proximity Read

Applying C. elegans to the Industrial Drug Discovery Process to Slow AgingSemantic proximity Read

Proximate Causes of Ageing Are Likely Evolutionarily Bound and Appropriate Countermeasure Design Requires New Approaches<strong> </strong>Semantic proximity Read

Mutation of daf-2 extends lifespan via tissue-specific effectors that suppress distinct life-limiting pathologies.Semantic proximity Read

Genetic mapping of lifespan and mitochondrial stress response in C. elegansSemantic proximity Read

Identification by machine vision of the rate of motor activity decline as a lifespan predictor in C. elegans.Semantic proximity Read

Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process in C57BL/6J MiceSemantic proximity Read

Consolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing declineSemantic proximity Read