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Article

The role of cellular senescence in aging through the prism of Koch-like criteria.

Ageing research reviews - 1 Jan 2018

Yanai Hagai, Fraifeld Vadim E

Abstract excerpt

Since Hayflick's discovery of cellular senescence (CS), a great volume of knowledge in the field has been accumulated and intensively discussed. Here, we attempted to organize the evidence "for" and "against" the hypothesized causal role of CS in aging. For that purpose, we utilized robust Koch-like logical criteria, based on the assumption that some quantitative relationships between the accumulation of...

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PMID: 29106993
DOI: 10.1016/j.arr.2017.10.004

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