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Senolytics and the compression of late-life mortality

2021-04-26

Abstract excerpt

Senescent cells play an important role in mammalian ageing and in the etiology of age-related diseases. Treatment of mice with senolytics – drugs that selectively remove senescent cells – causes an extension of median lifespan but has little effect on maximum lifespan. Postponement of some mortality to later ages, without a corresponding increase in maximum mortality, can be termed ‘compression of mortality’. When...

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Identifiers and source

Literature Corpus work
ed5b1d72-c1e6-5224-a044-a7e58106f82e
DOI
10.1101/2021.04.24.441236
Open publication

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Senolytics and the compression of late-life mortalityDOI 10.1101/2021.04.24.441236
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