Article

Single-cell analysis of hepatoblastoma identifies distinct tumor cell signatures that predict susceptibility to chemotherapy using patient-specific tumor spheroids

2021-10-15

Abstract excerpt

<h4>ABSTRACT</h4> Pediatric hepatoblastoma (HB) is the most common primary liver cancer in infants and children. Studies of HB that focus exclusively on tumor cells demonstrate sparse somatic mutations and a common cell of origin, the hepatoblast, across patients. In contrast to the homogeneity these studies would suggest, HB tumors have a high degree of heterogeneity that can portend poor prognosis. In this stud...

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Literature Corpus work: 3594f7d5-3fa5-579f-bd18-d683c2dfd99c
DOI: 10.1101/2021.10.13.464268

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