Bayesian colocalization of psychiatric disorder GWAS signals with molecular quantitative trait loci highlights histone involvement and neuroimmune dysregulation in pathogenesis.

Abstract excerpt

Genome-wide association studies (GWAS) have revolutionized our understanding of the genetic architecture of psychiatric disorders. However, the interpretation of these findings remains challenging, as most risk loci reside in non-coding regions, obscuring the underlying molecular mechanisms. To elucidate the functional consequences of psychiatric risk variants, we implemented a multi-omics Bayesian colocalization...

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