Article

BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved antitumor activity

2021-11-19

Abstract excerpt

<h4>Purpose</h4> The solid tumor microenvironment (TME) drives T cell dysfunction and inhibits the effectiveness of immunotherapies such as chimeric antigen receptor-based T cell (CAR T) cells. Early data has shown that modulation of T cell metabolism can improve intratumoral T cell function in preclinical models. <h4>Experimental Design</h4> We evaluated GPC3 expression in human normal and tumor tissue specimen...

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Literature Corpus work: 356a8f5e-6708-5c91-872c-ca7b7c94d94b
DOI: 10.1101/2021.11.17.469041

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