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Ablation of glypican-3 enhances radiosensitivity in liver cancer by prolonging G2/M arrest and activating the ATM/CHK2 pathway

2026-05-14

Abstract excerpt

Glypican-3 (GPC3) is an oncofetal protein widely being explored as a diagnostic and therapeutic target in hepatocellular carcinoma (HCC). Given that radiotherapy in the form of external beam and radioembolization are standard-of-care treatments for HCC, we aimed to determine whether there was any relationship between GPC3 and response to radiotherapy. Here, we demonstrate that GPC3 expression confers radioresistan...

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Identifiers and source

Literature Corpus work
e443fd6e-89bc-595d-83c7-e6aadf1ac68b
DOI
10.64898/2026.05.11.724294
Open publication

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Ablation of glypican-3 enhances radiosensitivity in liver cancer by prolonging G2/M arrest and activating the ATM/CHK2 pathwayDOI 10.64898/2026.05.11.724294
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