Article
Warburg phenotype in renal cell carcinoma: high expression of glucose-transporter 1 (GLUT-1) correlates with low CD8(+) T-cell infiltration in the tumor.
International journal of cancer - 1 May 2011
Singer Katrin, Kastenberger Michael, Gottfried Eva, Hammerschmied Christine G, Büttner Maike, Aigner Michael, Seliger Barbara, Walter Bernhard, Schlösser Hans, Hartmann Arndt, Andreesen Reinhard, Mackensen Andreas, Kreutz Marina
Abstract excerpt
Many tumor cells are characterized by a dysregulated glucose metabolism associated with increased glycolysis in the presence of oxygen ("Warburg Effect"). Here, we analyzed for the first time a possible link between glucose metabolism and immune cell infiltration in renal cell carcinoma (RCC). RCC specimens revealed a highly significant increase in the expression of lactate dehydrogenase A (LDHA) and...
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