Article
Identifying causal serum protein-cardiometabolic trait relationships using whole genome sequencing.
Human molecular genetics - 6 Apr 2023
Png Grace, Gerlini Raffaele, Hatzikotoulas Konstantinos, Barysenka Andrei, Rayner N William, Klarić Lucija, Rathkolb Birgit, Aguilar-Pimentel Juan A, Rozman Jan, Fuchs Helmut, Gailus-Durner Valerie, Tsafantakis Emmanouil, Karaleftheri Maria, Dedoussis George, Pietrzik Claus, Wilson James F, de Angelis Martin Hrabe, Becker-Pauly Christoph, Gilly Arthur, Zeggini Eleftheria
Abstract excerpt
Cardiometabolic diseases, such as type 2 diabetes and cardiovascular disease, have a high public health burden. Understanding the genetically determined regulation of proteins that are dysregulated in disease can help to dissect the complex biology underpinning them. Here, we perform a protein quantitative trait locus (pQTL) analysis of 248 serum proteins relevant to cardiometabolic processes in 2893 individuals....
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