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Endurance Exercise Ameliorates Aging-Related Bradyarrhythmia in <i>Drosophila</i> Resulting from miR-283 Knockdown in LN <sub>v</sub> s

2025-03-01

Abstract excerpt

MicroRNAs (miRNAs) are crucial in regulating cardiac aging and related diseases, yet few functional miRNAs have been identified. Prior studies showed miR-216a upregulation in heart failure patients, but its impact on aging hearts is unknown. Our study revealed systemic miR-283 overexpression or knockdown caused age-related bradycardia, mimicking human bradyarrhythmia. Importantly, we found that knockdown of miR-28...

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Literature Corpus work
3529e7e4-d80c-582a-b1c0-e816f1355472
DOI
10.1101/2025.02.25.640161
Open publication

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Endurance Exercise Ameliorates Aging-Related Bradyarrhythmia in <i>Drosophila</i> Resulting from miR-283 Knockdown in LN <sub>v</sub> sDOI 10.1101/2025.02.25.640161
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