Article
KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging.
Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2007
Ocorr Karen, Reeves Nick L, Wessells Robert J, Fink Martin, Chen H-S Vincent, Akasaka Takeshi, Yasuda Soichiro, Metzger Joseph M, Giles Wayne, Posakony James W, Bodmer Rolf
Abstract excerpt
Population profiles of industrialized countries show dramatic increases in cardiovascular disease with age, but the molecular and genetic basis of disease progression has been difficult to study because of the lack of suitable model systems. Our studies of Drosophila show a markedly elevated incidence of cardiac dysfunction and arrhythmias in aging fruit fly hearts and a concomitant decrease in the expression of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.