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Proinflammatory macrophage-derived medium enhances temozolomide sensitivity in glioblastoma via pSTAT3-mediated downregulation of DNA repair enzymes

2025-02-18

Abstract excerpt

<title>Abstract</title> <p>Chemoresistance to temozolomide (TMZ), the main agent in glioblastoma (GBM) treatment, negatively impacts prognosis due to efficient repair of TMZ-induced DNA lesions. Reduced expression of the DNA repair enzyme O6-methylguanine DNA-methyltransferase (MGMT) has been associated with improved chemotherapy response, though not consistently across patients. Our previous findings suggested t...

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Literature Corpus work
351ecb64-519a-59df-a825-e95f9c6c65a4
DOI
10.21203/rs.3.rs-5991999/v1
Open publication

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Proinflammatory macrophage-derived medium enhances temozolomide sensitivity in glioblastoma via pSTAT3-mediated downregulation of DNA repair enzymesDOI 10.21203/rs.3.rs-5991999/v1
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