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Article

DNA damage repair alterations modulate M2 polarization of microglia to remodel the tumor microenvironment via the p53-mediated MDK expression in glioma

14 Feb 2019

Abstract excerpt

BACKGROUND: DNA damage repair (DDR) alterations are important events in cancer initiation, progression, and therapeutic resistance. However, the involvement of DDR alterations in glioma malignancy needs further investigation. This study aims to characterize the clinical and molecular features of gliomas with DDR alterations and elucidate the biological process of DDR alterations that regulate the cross talk...

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Share to Ferroptosis and cancer prognosis
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PMID: 30773478
DOI: 10.1016/j.ebiom.2019.01.067

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