Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glioblastoma with high O6-methyl-guanine DNA methyltransferase expression are more immunologically active than tumors with low MGMT expression

15 Jan 2024

Abstract excerpt

Background Glioblastoma (GBM) is a highly lethal brain tumor. The effectiveness of temozolomide (TMZ) treatment in GBM is linked to the methylation status of O6-methyl-guanine DNA methyltransferase (MGMT) promoter. Patients with unmethylated MGMT promoter have limited treatment options available. Consequently, there is a pressing need for alternative therapeutic strategies for such patients. Methods Data,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Glioma Diagnosis and Treatment
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38288307
DOI: 10.3389/fimmu.2024.1328375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glioblastoma with high O6-methyl-guanine DNA methyltransferase expression are more immunologically active than tumors with low MGMT expressionPMID 38288307Read ↗

Molecular and clinicopathological characterization of a prognostic immune gene signature associated with MGMT methylation in glioblastomaSemantic proximity Read ↗

N6-Methyladenosine Regulator-Mediated Immue Patterns and Tumor Microenvironment Infiltration Characterization in GlioblastomaSemantic proximity Read ↗

DNA methylation heterogeneity attributable to a complex tumor immune microenvironment prompts prognostic risk in glioma.Semantic proximity Read ↗

Identification of m6A methyltransferase-related WTAP and ZC3H13 predicts immune infiltrates in glioblastomaSemantic proximity Read ↗

Genome wide DNA methylation landscape reveals glioblastoma’s influence on epigenetic changes in tumor infiltrating CD4+ T cellsSemantic proximity Read ↗

Machine learning and multi-omics analysis reveal key regulators of proneural–mesenchymal transition in glioblastomaSemantic proximity Read ↗

Tim-3 Expression and MGMT Methylation Status Association With Survival in GlioblastomaSemantic proximity Read ↗

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights tumor-promoting macrophage cells in GlioblastomaSemantic proximity Read ↗

Identification of Immune Cell Infiltration and Immune-Related Genes in the Tumor Microenvironment of GlioblastomasSemantic proximity Read ↗

A Novel DNA Methylation-Based Signature Can Predict the Responses of MGMT Promoter Unmethylated Glioblastomas to TemozolomideSemantic proximity Read ↗

Immune Microenvironment in Glioblastoma Subtypes.Semantic proximity Read ↗

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in GlioblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.