Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis.

doi:10.1158/1078-0432.CCR-13-0525

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Article

Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2013

Sanford Dominic E, Belt Brian A, Panni Roheena Z, Mayer Allese, Deshpande Anjali D, Carpenter Danielle, Mitchem Jonathan B, Plambeck-Suess Stacey M, Worley Lori A, Goetz Brian D, Wang-Gillam Andrea, Eberlein Timothy J, Denardo David G, Goedegebuure Simon Peter, Linehan David C

Abstract excerpt

PURPOSE: To determine the role of the CCL2/CCR2 axis and inflammatory monocytes (CCR2(+)/CD14(+)) as immunotherapeutic targets in the treatment of pancreatic cancer. EXPERIMENTAL DESIGN: Survival analysis was conducted to determine if the prevalence of preoperative blood monocytes correlates with survival in patients with pancreatic cancer following tumor resection. Inflammatory monocyte prevalence in the blood...

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Identifiers

PMID: 23653148
DOI: 10.1158/1078-0432.CCR-13-0525
PMCID: PMC3700620

Genes

CCR2
CCL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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