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Lentiviral CRISPRa/i in the adult Prairie Vole Brain: Modulating Neuronal Gene Expression Without DNA Cleavage

2025-03-31

Abstract excerpt

Prairie voles ( Microtus ochrogaster ) are a powerful model for studying the neurobiology of social bonding, yet tools for region- and cell type-specific gene regulation remain underdeveloped in this species. Here, we present a lentivirus-mediated CRISPR activation and interference (CRISPRa/i) platform for somatic gene modulation in the prairie vole brain. This system enables non-mutagenic, titratable regulation...

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Literature Corpus work
8f8d5929-5bc3-5a1d-ac17-c11abbdc9c74
DOI
10.1101/2025.03.30.646142
Open publication

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Lentiviral CRISPRa/i in the adult Prairie Vole Brain: Modulating Neuronal Gene Expression Without DNA CleavageDOI 10.1101/2025.03.30.646142
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