Article

Characterization of HLA-restricted GAD65-specific CD8 <sup>+</sup> T cell responses in patients with GAD65 antibody-associated neurological disorders

2026-05-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> High-titer glutamic acid decarboxylase 65 (GAD65) antibodies are found in patients with GAD65 antibody-associated neurological disorders, including stiff-person syndrome (SPS), GAD65 cerebellar ataxia (CA), and GAD65 epilepsy. Given the intracellular localization of the antigenic target, a direct pathogenic role for GAD65 autoantibodies is unlikely. Instead, the autoantibody...

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Literature Corpus work: 34fa8374-d2de-5821-8dac-e955ae2cb114
DOI: 10.64898/2026.05.20.726502

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