Article
A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies.
Brain : a journal of neurology - 1 Mar 2023
Strippel Christine, Herrera-Rivero Marisol, Wendorff Mareike, Tietz Anja K, Degenhardt Frauke, Witten Anika, Schroeter Christina, Nelke Christopher, Golombeck Kristin S, Madlener Marie, Rüber Theodor, Ernst Leon, Racz Attila, Baumgartner Tobias, Widman Guido, Doppler Kathrin, Thaler Franziska, Siebenbrodt Kai, Dik Andre, Kerin Constanze, Räuber Saskia, Gallus Marco, Kovac Stjepana, Grauer Oliver M, Grimm Alexander, Prüss Harald, Wickel Jonathan, Geis Christian, Lewerenz Jan, Goebels Norbert, Ringelstein Marius, Menge Til, Tackenberg Björn, Kellinghaus Christoph, Bien Christian G, Kraft Andrea, Zettl Uwe, Ismail Fatme Seval, Ayzenberg Ilya, Urbanek Christian, Sühs Kurt-Wolfram, Tauber Simone C, Mues Sigrid, Körtvélyessy Peter, Markewitz Robert, Paliantonis Asterios, Elger Christian E, Surges Rainer, Sommer Claudia, Kümpfel Tania, Gross Catharina C, Lerche Holger, Wellmer Jörg, Quesada Carlos M, Then Bergh Florian, Wandinger Klaus-Peter, Becker Albert J, Kunz Wolfram S, Meyer Zu Hörste Gerd, Malter Michael P, Rosenow Felix, Wiendl Heinz, Kuhlenbäumer Gregor, Leypoldt Frank, Lieb Wolfgang, Franke Andre, Meuth Sven G, Stoll Monika, Melzer Nico
Abstract excerpt
Autoimmune neurological syndromes (AINS) with autoantibodies against the 65 kDa isoform of the glutamic acid decarboxylase (GAD65) present with limbic encephalitis, including temporal lobe seizures or epilepsy, cerebellitis with ataxia, and stiff-person-syndrome or overlap forms. Anti-GAD65 autoantibodies are also detected in autoimmune diabetes mellitus, which has a strong genetic susceptibility conferred by...
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