Hepatocyte nuclear factor 4α in the intestinal epithelial cells protects against inflammatory bowel disease

Abstract excerpt

BACKGROUND: Hepatocyte nuclear factor 4alpha (HNF4alpha; NR2A1) is an orphan member of the nuclear receptor superfamily expressed in liver and intestine. While HNF4alpha expression is critical for liver function, its role in the gut and in the pathogenesis of inflammatory bowel disease (IBD) is unknown. METHODS: Human intestinal biopsies from control and IBD patients were examined for expression of mRNAs encoding...

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