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Article

Chromatin profiling reveals regulatory network shifts and a protective role for hepatocyte nuclear factor 4α during colitis.

Molecular and cellular biology - 1 Sept 2014

Chahar Sanjay, Gandhi Vishal, Yu Shiyan, Desai Kinjal, Cowper-Sal-lari Richard, Kim Yona, Perekatt Ansu O, Kumar Namit, Thackray Joshua K, Musolf Anthony, Kumar Nikhil, Hoffman A, Londono Douglas, Vazquez Berta N, Serrano Lourdes, Shin Hyunjin, Lupien Mathieu, Gao Nan, Verzi Michael P

Abstract excerpt

Transcriptional regulatory mechanisms likely contribute to the etiology of inflammatory bowel disease (IBD), as genetic variants associated with the disease are disproportionately found at regulatory elements. However, the transcription factors regulating colonic inflammation are unclear. To identify these transcription factors, we mapped epigenomic changes in the colonic epithelium upon inflammation. Epigenetic...

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Identifiers

PMID: 24980432
DOI: 10.1128/MCB.00349-14
PMCID: PMC4135557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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