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Article

Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer

11 May 2016

Abstract excerpt

HNF4α has been implicated in colitis and colon cancer in humans but the role of the different HNF4α isoforms expressed from the two different promoters (P1 and P2) active in the colon is not clear. Here, we show that P1-HNF4α is expressed primarily in the differentiated compartment of the mouse colonic crypt and P2-HNF4α in the proliferative compartment. Exon swap mice that express only P1- or only P2-HNF4α have...

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PMID: 27166517
DOI: 10.7554/elife.10903

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