Article

Extracellular histones stimulate collagen expression and potentially promote liver fibrogenesis via TLR4-MyD88 signalling pathway

2020-09-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually. Fibrosis develops from recurrent liver injury but the molecular mechanisms are not fully understood. Recently, the Toll-like receptor (TLR) 4-MyD88 signalling pathway has been reported to contribute to fibrosis. Extracellular histones are the l...

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Literature Corpus work: 34df5e37-2f18-5c15-8434-f55fbed62138
DOI: 10.1101/2020.09.17.302240

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