Article

Extracellular Histone 3.3 and Its Hyper-acetylated Isoform In-duce an Inflammatory Response and Damage Lung Tissue

2023-05-17

Abstract excerpt

Excessive extracellular histones can damage cells despite their importance in DNA structure and gene regulation. We previously showed the harmful effect of histone 3.3 (H3.3) and its acetylated form (AcH3.3) in chronic obstructive pulmonary disease (COPD), but further research is needed to understand the in vivo underlying mechanisms. To investigate this, we administered a single dose of recombinant histones via i...

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Literature Corpus work: 368e750f-40ad-52a7-bf59-4d785f7c8d8e
DOI: 10.20944/preprints202305.1200.v1

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