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Article

Targeting extranuclear histones to alleviate acute and chronic inflammation

12 Jun 2024

Abstract excerpt

Extracellular histones instigate an inflammatory triad - centered on cytotoxicity, immune cell stimulation, and coagulation - ultimately shaping the dynamics and outcome of various inflammatory pathologies. Given the virtual absence of beneficial functions of histones in the extracellular space, in recent years a number of interference strategies have emerged. In this review we summarize pathogenic functions of...

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PMID: 38853103
DOI: 10.1016/j.tips.2024.05.008

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