Article

The role of extracellular histones in critical illness and their application in acute pancreatitis

2017-01-01

Abstract excerpt

Histones are basic nuclear proteins that bind to genomic DNA. There are five subclasses: core histones H2A, H2B, H3 and H4, and linker histone H1. Release of extracellular histones has been shown in a range of critical illness animal models and human patients including sepsis and acute pancreatitis. Extracellular histones act as damage-associated molecular pattern molecules (DAMPs) on parenchymal epithelial and en...

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Literature Corpus work: 23a02bef-7b08-51fc-94e9-de5a7a7de9d1
DOI: 10.17638/03006800

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