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Parthanatos-inducing zinc agent C010DS-Zn elicits anti-tumor immune responses involving T cells and macrophages <i>in vivo</i>

2021-03-19

Abstract excerpt

Immune checkpoint inhibitors opened a new horizon in cancer therapy by enabling durable and complete responses in patients, but their wider application against general solid cancers has been hampered by the lack of a broadly acting anti-cancer immune response initiating agents. Parthanatos is a previously unexplored immunogenic programmed necrosis mechanism that is triggered by the hyperactivation of PARP DNA repa...

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Literature Corpus work
34dad2e0-bb22-5167-942c-4ac881097eb6
DOI
10.1101/2021.03.18.433812
Open publication

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