Necrocide 1 Mediates a Non-Apoptotic Necrotic Cell Death and Immunogenic Response in Human Cancer Cells

Abstract excerpt

<title>Abstract</title><p>Many anticancer agents induce apoptosis, mitotic catastrophe or senescence. Here, we report the functional characterization of an experimental inducer of TNF-independent necrosis, necrocide-1 (NC1). NC1 (but not its stereoisomer) killed a panel of human cancer cell lines (but not normal cells) at nanomolar concentrations and induced a non-apoptotic, necrotic morphotype, both<italic>in vit...

Topics

Open a Topic to create a Post that cites this publication.

• Apoptosis
• Autophagy in Disease and Therapy
• Cancer-related Molecular Pathways
• Cell Death
• Cell death mechanisms and regulation
• Gene Expression Regulation
• Phagocytosis and Immune Regulation
• RNA Interference and Gene Delivery

Identifiers and source

Literature Corpus work

20666721-36bc-56ac-a4b0-d7918327070b

DOI

10.21203/rs.3.rs-2090541/v1