Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Necrocide 1 mediates necrotic cell death and immunogenic response in human cancer cells

5 Apr 2023

Abstract excerpt

Many anticancer agents induce apoptosis, mitotic catastrophe or cellular senescence. Here, we report the functional characterization of an experimental inducer of tumor necrosis factor (TNF)-independent necrosis, necrocide-1 (NC1). NC1 (but not its stereoisomer) killed a panel of human cancer cells (but not normal cells) at nanomolar concentrations and with a non-apoptotic, necrotic morphotype, both in vitro and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to Phagocytosis and Immune Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37015922
DOI: 10.1038/s41419-023-05740-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Necrocide 1 mediates necrotic cell death and immunogenic response in human cancer cellsPMID 37015922Read ↗

Necrocide 1 Mediates a Non-Apoptotic Necrotic Cell Death and Immunogenic Response in Human Cancer CellsSemantic proximity Read ↗

Regulated cell death pathways: New twists in modulation of BCL2 family functionSemantic proximity Read ↗

The role of necroptosis in the treatment of diseasesSemantic proximity Read ↗

Comprehensive landscape of cell death mechanisms: from molecular cross-talk to therapeutic innovation in oncologySemantic proximity Read ↗

Necroptosis in cancer: An angel or a demon?Semantic proximity Read ↗

Programmed cell death with a necrotic-like phenotype.Semantic proximity Read ↗

Necroptosis: Mechanisms and Relevance to DiseaseSemantic proximity Read ↗

Targeting Programmed Cell Death Using Small‐Molecule Compounds to Improve Potential Cancer TherapySemantic proximity Read ↗

Relevance of necroptosis in cancerSemantic proximity Read ↗

Necroptotic cell death in anti‐cancer therapySemantic proximity Read ↗

The in vivo evidence for regulated necrosisSemantic proximity Read ↗

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.